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Paing Phyo Thu is a Myanmar Academy Award winning Burmese film actress and a medical doctor. She won the Myanmar Academy Award for Best Supporting Actress in 2017 Myanmar Motion Picture Academy Awards with the film, 3Girls. Paing Phyo Thu is considered one of the promising and prominent actresses in Myanmar. Paing Phyo Thu was born on 5 April 1990 in Yangon, Myanmar. Her mother Nwe Oo, is a physician. She passed the matriculation from TTC Yangon in 2006. She graduated from the University of Medicine 1, Yangon. She served as Health Ambassador (Yangon Division) for Ministry of Health and Sports in 2018. Paing Phyo Thu started her career as a child actor in 1999. Her performances as child actor stood out and she became an actress in Myanmar major films in later years. In 2017, she was cast to play a lead role in the film Mi which is based on the novel by one of the most prominent Myanmar novelists, Kyi Aye.Although expectations were high, the film was well received by the audience. The film release was followed by some criticism on her portrayal of character Mi who is a chain-smoker.She stood firmly of her portrayal of Mi by giving up her title of Health Ambassador (Yangon Division) for Ministry of Health and Sports. She won the Best Actress Award for her performance in Mi (film) at Star Awards (2018). She was nominated (Best Actress) for her performance in Mi (film) at ASEAN International Film Festival and Awards (2019). In 2021, she was also nominated for Best Performance (Seymour Cassel Award) in What Happened to the Wolf? at Oldenburg International Film Festival (2021).